Pattern of Renal Blood Flow in Sickle Cell Disease Adult Patients

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Categories: Abstracts


Introduction/Patient Description

Sickle cell disease (SCD) patient are at risk of developing sickle nephropathy (SN). The aim of this study was to evaluate renal blood flow patterns and reno-vascular parameters in adult SCD patients without laboratory evidence of renal impairment.

Methods

Sixty-five steady-state adult patients with SCD (50 SS, 12 HbSβ0, and 3 SD), aged 32.89 ± 13.89 years and 30 age- and sex-matched healthy controls were studied. Kidney length, echo pattern, peak systolic velocity (PSV), end-diastolic velocity (EDV), renal-aortic ratio (RAR), resistive index (RI), acceleration time (AT), and renal vein velocity (RVV) were acquired, recorded, and analyzed using a curvilinear transducer of 1-5MHz through the abdomen.

Results

The highest mean for ultrasound renal length and cortical thickness in the SCD and control groups were 11.78 ± 1.30cm and 11.27 ± 0.77cm, and 1.86 ± 0.41cm and 1.78 ± 0.28cm, respectively. The figures were significantly higher in the SCD patients group than the control group (P < 0.05). Sixty (90.8%) patients had a mild diffuse increase in cortical echogenicity with preserved renal cortical thickness. The highest mean extra-renal PSV in the SCD and control groups were 138.46 ± 56.32cm/s and 101.75 ± 31.48 cm/s, respectively (P < .05). However, the highest intra-renal RI and AT in SCD and control groups were 0.69 ± 0.07 and 0.06 ± 0.02s and 0.63 ± 0.05 and 0.04 ± 0.01s, respectively (P < .05). There was no significant correlation between RI and AT and PSV among the patients with SCD (P>.05).

Conclusion/Discussion

Increased renal length and cortical echogenicity with elevated PSV and RI and AT values can serve as early sonographic changes in SCD adult patients without renal impairment.

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Presented by

Akram Asbeutah, Associate Professor/Dr, Kuwait University